Design of a microfluidic respirometer for semi-continuous amperometric short time biochemical oxygen demand (BOD<sub>st</sub>) analysis

TitleDesign of a microfluidic respirometer for semi-continuous amperometric short time biochemical oxygen demand (BODst) analysis
Publication TypeJournal Article
Year of Publication2012
AuthorsTorrents A., Mas J., Muñoz F.X, del Campo F.J
JournalBiochemical Engineering Journal
Volume66
Pagination27-37
Date PublishedJul
Type of ArticleArticle
ISBN Number1369-703X
Accession NumberWOS:000306041600005
Keywordsbiosensors, Biotechnology & Applied Microbiology, BOD biosensor, diffusion, Electrochemistry, electrodes, Engineering, Finite element method, kinetics, membranes, Microfluidics, Modeling, Respirometry, sensors
Abstract

This paper presents the design of a miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current biochemical oxygen demand, BOD. methods. We demonstrate the use of finite element method simulations as design tool for a novel concept microfluidic respirometer. The device is based on a flow cell separated by a thin membrane from a bioreactor. Simulations show that once membrane material and thickness are chosen, oxygen supply rate still provides sufficient flexibility to allow the measurement of samples spanning a very wide range of organic matter concentrations. The design presented here uses an electrochemical oxygen sensor, and the whole system is amenable to fabrication using standard microfabrication and rapid prototyping techniques. (c) 2012 Elsevier B.V. All rights reserved.

Short TitleBiochem. Eng. J.Biochem. Eng. J.
Alternate JournalBiochem. Eng. J.
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Times Cited: 9
Cited Reference Count: 44
Torrents, Albert Mas, Jordi Xavier Munoz, Francesc Javier del Campo, Francisco
Mas, Jordi/A-5342-2008; del Campo, F. Javier/J-6738-2012; Mas, Jordi/ABH-8190-2020; Munoz, PacoXavi/J-3386-2012
Mas, Jordi/0000-0002-1980-4522; del Campo, F. Javier/0000-0002-3637-5782; Mas, Jordi/0000-0002-1980-4522; Munoz, PacoXavi/0000-0002-9358-6340
Microresp [PET2008-0165-01]; MEDRA [TSI020100-2011-187]; Bactotox [CTQ2009-14390-C02-01, CTQ2009-14390-C02-02]; TRAGUA [CSD2006-00044]; FPU scholarship [AP2008-03848]
The authors acknowledge funding through projects Microresp (PET2008-0165-01), MEDRA (TSI020100-2011-187), Bactotox (CTQ2009-14390-C02-01 and CTQ2009-14390-C02-02) and TRAGUA (CSD2006-00044). In addition, Albert Torrents is funded by a FPU scholarship (AP2008-03848). We also thank Neus Godino for her help and advice in the modeling process
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57
Elsevier
Amsterdam
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del Campo, FJ (corresponding author), Esfera UAB, IMB, CNM, CSIC, Campus Univ Autonoma Barcelona, Barcelona 08193, Spain.
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